21c Museum Hotel Louisville

About this place 21c Museum Hotel Louisville

The 21c Museum Hotel Louisville is the original property in the 21c chain — the Louisville founders Adam Speed Watkins and Laura Lee Brown opened the first 21c here in 2006, converting a group of historic warehouses on West Main Street into a hotel that incorporates a contemporary art museum open 24 hours to guests and the public alike. The concept has since expanded to multiple cities, but Louisville remains the flagship: the largest 21c property, the one with the longest track record, and the one most deeply embedded in the city's cultural life. The hotel is explicitly welcoming of LGBTQ+ guests — the 21c brand has been consistently supportive of the LGBTQ+ community from its founding, and the Louisville property has hosted Pride events, LGBTQ+ film screenings, and community programming throughout its history. The art collection on permanent display throughout the hotel includes works that engage with queer identity and LGBTQ+ themes. The Proof on Main restaurant is one of Louisville's best. The West Main Street location is within walking distance of NuLu, the Muhammad Ali Center, and the Louisville Slugger Museum.