Best Gay-Friendly Hotels in St. Louis

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Gay-Friendly Hotel 4.2 (1384)

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Grand Center

12 min walk to Hidden Gem

Colour-themed art hotel in Grand Center, St. Louis, close to the Fox Theatre and a short ride from The Grove.

Gay friendly Gay-friendly (straight venue) Card payments accepted

LGBTQ+ Friendly Oct 2026

21c Museum Hotel St Louis

Gay-Friendly Hotel 4.1 (929)

21c Museum Hotel St Louis

Gay-Friendly Hotel

19 min walk to The Club St. Louis

Hotel with public contemporary art galleries at 1528 Locust St, downtown west; about 10 minutes by car from The Grove.

Gay friendly Gay-friendly (straight venue) Card payments accepted

LGBTQ+ Friendly Oct 2026

The Cheshire

Gay-Friendly Hotel 4.1 (2137)

The Cheshire

Gay-Friendly Hotel

19 min walk to Prism

Literary-themed boutique hotel on Clayton Avenue by Forest Park, St. Louis, a mile or two from The Grove's gay bars; gay-friendly.

Gay friendly Gay-friendly (straight venue) Gay-popular

LGBTQ+ Friendly Oct 2026

Tru by Hilton St. Louis Downtown

Gay-Friendly Hotel 3.0 (304)

Tru by Hilton St. Louis Downtown

Gay-Friendly Hotel

24 min walk to The Club St. Louis

Budget Tru by Hilton at 1221 Locust St downtown, in the same building as Home2 Suites; about 10 minutes from The Grove.

Gay friendly Gay-friendly (straight venue) Gym

LGBTQ+ Friendly Oct 2026

Home2 Suites By Hilton St. Louis Downtown

Gay-Friendly Hotel 3.2 (413)

Home2 Suites By Hilton St. Louis Downtown

Gay-Friendly Hotel

24 min walk to The Club St. Louis

Extended-stay Home2 Suites on Locust Street, downtown St. Louis, with kitchenette suites; reviews are mixed.

Gay friendly Gay-friendly (straight venue) Card payments accepted

LGBTQ+ Friendly Oct 2026

Radisson Hotel St. Louis Downtown – Convention Center

Gay-Friendly Hotel 3.7 (2145)

Radisson Hotel St. Louis Downtown – Convention Center

Gay-Friendly Hotel

31 min walk to The Club St. Louis

Large convention-area hotel at 811 N 9th St, downtown St. Louis; walkable to PrideFest, a short drive to The Grove.

Gay friendly Gay-friendly (straight venue) Pool

LGBTQ+ Friendly Oct 2026

The Westin St. Louis

Gay-Friendly Hotel 4.2 (2324)

The Westin St. Louis

Gay-Friendly Hotel

35 min walk to Bastille

Upscale Marriott-brand hotel at 811 Spruce St, a block from Busch Stadium; walkable to downtown PrideFest, 10 minutes to The Grove.

Gay friendly Gay-friendly (straight venue) Year-round

LGBTQ+ Friendly Oct 2026

Drury Plaza Hotel St. Louis At The Arch

Gay-Friendly Hotel 4.6 (3669)

Drury Plaza Hotel St. Louis At The Arch

Gay-Friendly Hotel

41 min walk to The Club St. Louis

Large downtown hotel steps from the Gateway Arch, with an indoor pool and free hot breakfast.

Gay friendly Gay-friendly (straight venue) Pool

LGBTQ+ Friendly Oct 2026

Days Inn by Wyndham Downtown St. Louis

Gay-Friendly Hotel 2.6 (1095)

Days Inn by Wyndham Downtown St. Louis

Gay-Friendly Hotel

44 min walk to The Club St. Louis

Budget Days Inn on North 9th Street, north of downtown St. Louis near I-70. Low ratings and car-dependent.

Gay friendly Gay-friendly (straight venue) WiFi

LGBTQ+ Friendly Oct 2026

Moonrise Hotel

Gay-Friendly Hotel 4.5 (2651)

Moonrise Hotel

Gay-Friendly Hotel

75 min walk to Platypus

Space-themed boutique hotel on the Delmar Loop in St. Louis, with a rooftop bar and on-site restaurant.

Gay friendly Gay-friendly (straight venue) Card payments accepted

LGBTQ+ Friendly Oct 2026

Principal Hotel Columbia

Gay-Friendly Hotel 4.7 (82)

Principal Hotel Columbia

Gay-Friendly Hotel

213 min walk to Bar:PM

Small boutique hotel on Main Street in Columbia, Illinois, about 25 minutes south of downtown St. Louis.

Gay friendly Gay-friendly (straight venue) WiFi

LGBTQ+ Friendly Oct 2026