The gay scene in Santiago is massive, particularly in the Bellavista neighbourhood, probably the largest in all of South America outside of Sao Paolo.
The city is also home to an exciting wine culture with world-class wineries to visit, lots of impressive city street art to awe at, tons of outdoor adventures like paragliding to try out, and natural hot springs to relax in, Andes mountains right (between Santiago de Chile and Mendoza, Argentina) etc.